Brain perfusion anomalies in rapid eye movement sleep behavior disorder with mild cognitive impairment
Identifieur interne : 001462 ( Main/Exploration ); précédent : 001461; suivant : 001463Brain perfusion anomalies in rapid eye movement sleep behavior disorder with mild cognitive impairment
Auteurs : Mélanie Vendette [Canada] ; Jacques Montplaisir [Canada] ; Nadia Gosselin [Canada] ; Jean-Paul Soucy [Canada] ; Ronald B. Postuma [Canada] ; Thien Thanh Dang-Vu [Canada, Belgique] ; Jean-François Gagnon [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2012-09-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Behavior, Cerebral disorder, Cognitive disorder, Encephalon, Lewy body dementia, Nervous system diseases, Parkinson disease, Parkinson's disease, Photon, REM sleep behavior disorder, Rapid eye movement sleep, Regional blood flow, SPECT (regional cerebral blood flow), Single photon emission tomography, Sleep disorder, mild cognitive impairment.
Abstract
Rapid eye movement (REM) sleep behavior disorder is an important risk factor for Parkinson's disease and dementia with Lewy bodies. Approximately 50% of patients with REM sleep behavior disorder have mild cognitive impairment. Our objective was to investigate brain perfusion changes associated with mild cognitive impairment in REM sleep behavior disorder. Twenty patients with REM sleep behavior disorder, including 10 patients with mild cognitive impairment and 10 patients without mild cognitive impairment, and 20 healthy controls underwent a complete neuropsychological assessment and single‐photon emission computerized tomography using 99mcTc‐Ethylene Cysteinate Dimer. Compared with controls, both REM sleep behavior disorder groups had hypoperfusion in the frontal regions. In addition, patients with REM sleep behavior disorder and mild cognitive impairment showed cortical hypoperfusion in the occipital, temporal, and parietal regions compared with controls and patients with REM sleep behavior disorder without mild cognitive impairment. Both REM sleep behavior disorder groups had hyperperfusion in the right hippocampus and parahippocampal gyri. However, patients with REM sleep behavior disorder and mild cognitive impairment showed more pronounced anomalies in the right hippocampus and had increased perfusion in the putamen and the left paracentral gyrus. This study showed specific patterns of posterior cortical hypoperfusion and hyperperfusion in some brain areas in patients with REM sleep behavior disorder and mild cognitive impairment, similar to those found in Parkinson's disease dementia and dementia with Lewy bodies. This suggests the presence of an identifiable neuroimaging marker of synucleinopathy in REM sleep behavior disorder with mild cognitive impairment. © 2012 Movement Disorder Society
Url:
DOI: 10.1002/mds.25034
Affiliations:
- Belgique, Canada
- Province de Liège, Québec, Région wallonne
- Liège, Montréal
- Université McGill, Université de Liège, Université du Québec à Montréal
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Le document en format XML
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Gouin Ouest, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-09-01">2012-09-01</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1255">1255</biblScope><biblScope unit="page" to="1261">1261</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EDBBF9C9F88008EC29AC6032979A08BE61283D50</idno><idno type="DOI">10.1002/mds.25034</idno><idno type="ArticleID">MDS25034</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term><term>Cerebral disorder</term><term>Cognitive disorder</term><term>Encephalon</term><term>Lewy body dementia</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Photon</term><term>REM sleep behavior disorder</term><term>Rapid eye movement sleep</term><term>Regional blood flow</term><term>SPECT (regional cerebral blood flow)</term><term>Single photon emission tomography</term><term>Sleep disorder</term><term>mild cognitive impairment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term><term>Débit sanguin régional</term><term>Déficit cognitif léger</term><term>Démence à corps de Lewy</term><term>Encéphale</term><term>Maladie de Parkinson</term><term>Pathologie de l'encéphale</term><term>Pathologie du système nerveux</term><term>Photon</term><term>Sommeil paradoxal</term><term>Tomoscintigraphie émission monophotonique</term><term>Trouble cognitif</term><term>Trouble du sommeil</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder is an important risk factor for Parkinson's disease and dementia with Lewy bodies. Approximately 50% of patients with REM sleep behavior disorder have mild cognitive impairment. Our objective was to investigate brain perfusion changes associated with mild cognitive impairment in REM sleep behavior disorder. Twenty patients with REM sleep behavior disorder, including 10 patients with mild cognitive impairment and 10 patients without mild cognitive impairment, and 20 healthy controls underwent a complete neuropsychological assessment and single‐photon emission computerized tomography using 99mcTc‐Ethylene Cysteinate Dimer. Compared with controls, both REM sleep behavior disorder groups had hypoperfusion in the frontal regions. In addition, patients with REM sleep behavior disorder and mild cognitive impairment showed cortical hypoperfusion in the occipital, temporal, and parietal regions compared with controls and patients with REM sleep behavior disorder without mild cognitive impairment. Both REM sleep behavior disorder groups had hyperperfusion in the right hippocampus and parahippocampal gyri. However, patients with REM sleep behavior disorder and mild cognitive impairment showed more pronounced anomalies in the right hippocampus and had increased perfusion in the putamen and the left paracentral gyrus. This study showed specific patterns of posterior cortical hypoperfusion and hyperperfusion in some brain areas in patients with REM sleep behavior disorder and mild cognitive impairment, similar to those found in Parkinson's disease dementia and dementia with Lewy bodies. This suggests the presence of an identifiable neuroimaging marker of synucleinopathy in REM sleep behavior disorder with mild cognitive impairment. © 2012 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li></country><region><li>Province de Liège</li><li>Québec</li><li>Région wallonne</li></region><settlement><li>Liège</li><li>Montréal</li></settlement><orgName><li>Université McGill</li><li>Université de Liège</li><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></noRegion><name sortKey="Dang U, Thien Thanh" sort="Dang U, Thien Thanh" uniqKey="Dang U T" first="Thien Thanh" last="Dang-Vu">Thien Thanh Dang-Vu</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gosselin, Nadia" sort="Gosselin, Nadia" uniqKey="Gosselin N" first="Nadia" last="Gosselin">Nadia Gosselin</name><name sortKey="Gosselin, Nadia" sort="Gosselin, Nadia" uniqKey="Gosselin N" first="Nadia" last="Gosselin">Nadia Gosselin</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Soucy, Jean Aul" sort="Soucy, Jean Aul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><name sortKey="Soucy, Jean Aul" sort="Soucy, Jean Aul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Dang U, Thien Thanh" sort="Dang U, Thien Thanh" uniqKey="Dang U T" first="Thien Thanh" last="Dang-Vu">Thien Thanh Dang-Vu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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